As far as I understand, the US5000 has double the capacity (Ah) of the US2000.
You should consult both of your datasheets yourself, though.
But if this is the case, the stack of 4xUS5000 has the same capacity as our old stack with 8xUS2000.
Then you do not need to change anything in your setup…the BMS will report the necessary capabilities.
Just make sure, that the GX sees the BMS with 4 modules instead 8 after you did the swap.
If the capacity of the new stack is not the same, you need to adjust this in the set-up of the ESS or Powerassist Assistant in your quattro
I believe you can use both sets of batteries together, just make sure the newer US5000 are the master. You can use a Lynx Distributor (or more than one) to connect them and from there feed your inverter.
As a side note, while you can use one set of cables for several US2000, I would suggest that with the US5000, you run a set of cables from each battery to youyr distributor as the max current output from these larger batteries is near the max rating of the cables that Pylotech sell/supply. It will provide for a more stable and safe installation.